As the disease progresses, AD patients gradually lose their ability to think and reason clearly, make judgments, solve problems, communicate, and take care of themselves. Although AD develops differently for each individual, it normally presents similar symptoms in the early stages, the most common defect is remembering recent events or short-term memory impairment. This disease can occur in anyone at any age however, it is most common among the elderly and is less prevalent in younger people. IntroductionĪlzheimer’s disease (AD) is a progressive neurodegenerative disorder named by the German physician Dr. This review concentrates on the toxicity of A β and the mechanism of accumulation of this toxic protein in the brain of individuals with AD and also summarizes recent advances in the study of these accumulation mechanisms together with the role of herbal medicines that could facilitate the development of more effective therapeutic and preventive strategies. Lately, knowledge that may be critical to unraveling the hidden pathogenic pathway of AD has been revealed. Most previous studies have accepted the “amyloid hypothesis,” in which the neuropathogenesis of AD is believed to be triggered by the accumulation of the toxic amyloid beta (A β) protein in the central nervous system (CNS). There is no proven medication to cure or prevent the disease, possibly due to a lack of knowledge regarding the molecular mechanisms underlying disease pathogenesis.

While the number of individuals with AD is rising each year due to the longer life expectancy worldwide, current therapy can only somewhat relieve the symptoms of AD.

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that leads to memory deficits and death.

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